WTO Reform: Reflections on Reform Week and Suggested Approaches for Breakout Groups
A Note Reviewing the Process and Reform Tracks in Advance of WTO Reform Week, 5 December 2025
By Vahini Naidu, Trade for Development Programme, South Centre
This note provides an assessment of the papers circulated by the WTO Reform Facilitator for Reform Week and highlights the structural gaps that limit their balance and practical value to move forward these discussions in a manner that takes the demands and interests of developing and least developed country Members into account. The current drafts reflect a narrow interpretation of the consultations, introduce elements that were not examined collectively and overlook mandated issues that continue to shape the functioning of the system. This note sets out the adjustments that Members may wish to propose to restore a development centred framing, make a clear distinction between descriptive reflections and new reform ideas, and ensure that any work proceeds in line with Ministerial instructions for a member driven, transparent and inclusive process. The aim is to place the discussion on a footing that reflects the full range of Member views and respects the mandates already agreed.
Global South Development Achievements and Challenges
Global South Research Center Thematic Report (15 September 2025)
By Wang Jinzhao, Carlos Correa (South Centre), Zhang Youyi, Liu Chen, Liang Weitang, Carlos Oya, Len Ishmael, Li Yuefen (South Centre)
The rise of the Global South is a defining feature of the profound transformation reshaping the world. In recent years, Global South countries have achieved significant progress in their economic and social development. Compared with the beginning of the 21st century, the total economic output of the Global South has grown by approximately 5.4 times, an annual growth of 5.1%, significantly higher than the global average of 3.5%. Industrial development has accelerated, industrialization has kept advancing, and some competitive industries have been fostered. Trade and investment have substantially expanded. Goods exports and imports as well as outward investment have all increased about fivefold. Many emerging economies have increased their investment in research and development, resulting in continuous enhancement of innovation capabilities. Historic achievements have been made in poverty reduction, with over one billion people in the Global South lifted out of extreme poverty. Significant progress has been made in health. The average life expectancy has risen from around 62 years to approximately 70 years. Access to education has been increasingly expanding. The higher education enrollment rate increased from 13% to 38%.
The overall development advances made by the Global South have enabled it to have become a crucial force driving common development and improving global governance. It has increasingly played a significant role in the cause of human progress. The Global South, a key engine of global economic growth, accounts for 85% of the world’s population, around 40% of the global economy, 46% of global goods exports, 57% of global foreign direct investment inflows, 45% of global manufacturing output, and approximately 50% of intermediate goods exports. The Global South is also actively engaged in addressing global challenges. Its involvement in the reform of the global governance system enhances the representation and voice of developing countries. In the meantime, it keeps strengthening platforms for solidarity and cooperation among emerging economies and developing countries, such as BRICS. It pushes forward establishing new multilateral development banks and deepening regional cooperation.
The achievements of the Global South are due to an overall peaceful and stable international environment, ongoing economic globalization, and accelerated and diffusing technological innovation on a global scale, and, within Global South countries, a heightened sense of autonomy and commitment to market-based approaches combined with active government macro-regulation.
It should be recognized, however, that the Global South faces new challenges. External shocks have had negative impacts on Global South countries, including a sluggish global economy, broken multilateral trading rules, intensifying global climate risks, and increasing occurrences of regional conflict and instability. Within Global South countries, some face significant gaps in infrastructure, great difficulties in development financing including limited resources and high costs, and inadequate resources in education and healthcare.
Looking ahead, the Global South should continue to actively integrate into global industrial and supply chains, and strengthen dialogue and cooperation with the Global North, promoting the North and the South working together in the same direction. At the same time, the Global South should seize the opportunities, embrace the fundamental trends, and advance solidarity and cooperation among themselves with the vision of a community with a shared future for humanity. The Global South needs to deepen economic and trade cooperation based on the principles of mutual support and complementarity of advantages, expand trade and investment collaboration prospects, step up technology transfer and knowledge sharing, enhance autonomous development capabilities, and advance new developments in the Global South.
Balancing the Global Copyright System in the Public Interest: An Analysis of the African Group’s Proposed Instrument on Limitations and Exceptions
South Centre and Centre on Knowledge Governance Working Paper, 1 December 2025
By Faith O. Majekolagbe
The establishment of an international instrument on copyright limitations and exceptions (L&Es) is essential to achieve an appropriate balance between exclusive rights and the overarching public interest in access to copyrighted works and related subject matter. Current international copyright instruments, including the Marrakesh Treaty to Facilitate Access to Published Works for Persons who are Blind, Visually Impaired or Otherwise Print Disabled, fail to adequately address L&Es for education, research, equitable access for persons with disabilities, and the operations of educational, research, and cultural heritage institutions such as libraries, archives, and museums. The proposed instrument on L&Es by the African Group seeks to establish mandatory minimum L&Es to support education, research, and access to information within the international copyright system, thereby promoting global harmonization and ensuring that copyright law supports, not impedes, development objectives and compliance with human rights obligations. This working paper offers a thorough analysis of the proposed instrument, examining its substantive provisions and potential benefits.
Input to the Expert Mechanism on the Right to Development
Study on Artificial Intelligence, Cultural Rights, and the Right to Development
South Centre
November 2025
The South Centre submitted an input to the Expert Mechanism on the Right to Development regarding the study on “Artificial Intelligence, Cultural Rights, and the Right to Development.”
As Artificial Intelligence (AI) rapidly evolves, it presents a complex challenge for the international community. While AI holds the potential to advance human progress, unregulated deployment threatens to exacerbate existing global disparities and endanger the realisation of the Right to Development (RtD).
Key Policy Highlights from the Submission:
Addressing the AI Divide: Low and Middle-Income Countries (LMICs) face significant gaps in digital infrastructure and access to quality local datasets. To prevent the widening of global inequalities, governance frameworks must mandate technology transfer and capacity building without imposing restrictive intellectual property barriers.
Protecting Cultural Sovereignty: The mass accumulation of data by Generative AI models risks replicating historical patterns of “digital extractivism”. There is a need to increase transparency in training data protocols to prevent the misappropriation of traditional knowledge and cultural heritage.
Beyond Self-Regulation: Voluntary measures by the private sector lack essential mechanisms for external accountability and redress. A pragmatic regulatory approach is necessary: a legally binding global baseline for human rights accountability, complemented by flexible domestic regulations that preserve national policy space for local innovation.
To ensure AI serves humanity, the international community must move toward a governance model that guarantees global fairness, upholds human rights, and prevents market monopolisation by a few corporations.
Analysis of the European Union Proposal on the Pandemic Agreement Annex dated 17 October 2025
South Centre
This note is prepared to provide South Centre Member States and other developing country delegations with analytical comments on the proposal of the European Union (EU) on the Annex to the Pandemic Agreement, implementing the Pathogen Access and Benefit Sharing (PABS) System as established in Article 12. The note begins with general commentary on the proposal, followed by detailed analysis of the EU proposal text, which is marked in red below the transcribed text.
The GUIDE Framework for Evidence-based Antibiotic Prescribing
Strengthening Antimicrobial Stewardship for the Healthcare Workforce
By Dr. Rasha Abdelsalam Elshenawy
Antimicrobial resistance (AMR) poses a critical threat to global health security, with inappropriate antibiotic prescribing in hospitals driving the spread of resistant pathogens. This GUIDE Framework for Evidence-Based Antibiotic Prescribing provides a structured, five-step model designed to strengthen antimicrobial stewardship (AMS) and empower the healthcare workforce to make informed, proportionate prescribing decisions.
Report on Compulsory Licensing Provisions in the National Patent Legislation of 15 Middle-Income Countries:
A Content Analysis and Recommendations
A Report of the Global Economic Governance Initiative of the Boston University Global Development Policy Center
Published by the South Centre and the Global Economic Governance Initiative of Boston University Global Development Policy Center
This study examines compulsory licensing laws in 15 middle-income countries often excluded from voluntary licenses & finds significant untapped policy space to advance access to affordable medicines. It highlights best practices & makes key recommendations to improve patent laws for the use of this important TRIPS flexibility.
WTO Reform: Assessment of the Facilitator’s Communication and Process Ahead of the 4 November 2025 Plenary
An Informal Note Reviewing the Reform Tracks and Process in Advance of the 4 November Plenary, 2 November 2025
By Vahini Naidu, Trade for Development Programme, South Centre
This note provides an analytical assessment of the Facilitator’s Communication and process ahead of the WTO reform plenary held on 4 November 2025. It highlights the growing procedural opacity surrounding the reform process, characterised by informal, facilitator-led configurations that lack clear mandates, participation criteria, or official records of discussions. These methods have blurred the lines between Member-driven deliberation and Secretariat-managed processes, creating uncertainty over accountability, legitimacy and inclusiveness.
Substantively, the Facilitator’s synthesis elevates certain reform tracks, notably decision-making and level playing field, as forward-looking agendas, while confining the Development and S&DT track to a diagnostic or exploratory stage. This imbalance risks entrenching asymmetries rather than addressing them. By conflating S&DT with the broader development mandate, the Communication effectively narrows the systemic development agenda of the Marrakesh Agreement to a limited discussion of differentiation and eligibility.
Read together, the procedural and substantive dynamics reveal a process that is fragmented, imbalanced and at risk of being shaped by informal interpretations rather than by Member-driven decisions. The note calls for restoring transparency, reaffirming the primacy of consensus and re-centring development as the organising principle of WTO reform.
Gamani Corea and his Enduring Legacy for the Global South
By Danish
Gamani Corea was an intellectual giant of the global South, with a long and illustrious career spent in strengthening multilateralism and advancing the common interests of developing countries. On the occasion of Gamani Corea’s birth centenary on 4 November 2025, this paper revisits some of his most notable contributions in the different domains where he played important roles, and examines their relevance for addressing contemporary challenges facing the global South. It further explores his vision and impact as part of the South Commission and in establishing the South Centre. Amidst weakening multilateralism and rising geo-economic turmoil, this paper explores how Gamani Corea’s legacy offers both inspiration and practical insights for developing countries in reshaping global governance. His ambition to strengthen Southern solidarity and collective action at the multilateral level continues to provide essential guidance for developing countries to accelerate sustainable development and ensure that no one gets left behind.
The WIPO Patent Agenda: The Risks for Developing Countries
by Carlos M. Correa and Sisule F. Musungu
This paper is aimed at assessing some of the implications of the WIPO Patent Agenda, in the context of the ongoing debates on the benefits and costs of intellectual property protection for developing and least developed countries. The main aim of the paper is to provide an overview of the processes under the Patent Agenda, to identify and examine the main issues that are under discussion and to underscore the importance of these issues for developing and least-developed countries.
Building Up a Balanced Global Intellectual Property System: Report of the WIPO Assemblies’ Sixty-sixth Series of Meetings
Health, Intellectual Property and Biodiversity Programme, South Centre
This report reviews the key discussions and outcomes of the 66th Series of Meetings of the World Intellectual Property Organization (WIPO) Assemblies held in July 2025. The Assemblies addressed important governance, oversight, and norm-setting issues. Key developments included the launch of the process to appoint a new Director General, decisions on committee compositions and approval of the 2026/27 Program and Budget. Developing countries advocated for more inclusive participation in governance, balanced priority setting on norm-setting work, and stronger implementation of the Development Agenda.
Future of the UN Tax Committee under the UN Framework Convention on International Tax Cooperation
By Aisha Aize Isa, Sabrine Marsit, Abiodun Adewale Adegboye, Nyatefe Wolali Dotsevi, Anne Wanyagathi Maina and Abdul Muheet Chowdhary
The global tax governance landscape has recently undergone major shifts and is now at a pivotal momentum where demands of inclusivity, transparency and an equitable tax system are increasingly growing amongst countries. Central to this pivotal momentum is the creation of the United Nations Framework Convention on International Tax Cooperation (UNFCITC), mandated by United Nations (UN) General Assembly Resolution 78/230 (December 2023). The UNFCITC’s objective is to establish an intergovernmental platform for governance and cooperation in international taxation. This report aims at exploring the possible role of the UN Committee of Experts on International Cooperation in Tax Matters (UNTC) within the merging architecture of the UNFCITC, drawing on past lessons of efforts to democratize international tax governance.
